Result Test Name
CLINICAL INDICATION:
Laboratory
QUEST LAB
Result Test Code
123012211
Laboratory Test Name
QUEST FISH ALK 2P23 REA LUNG CANCER (NSCLC)
Reportable Test Name
-
Result LOINC
55752-0
Collection Container
PATH CONTAINER
Units
-
Collection Requirements
Preferred Specimen(s) Formalin-fixed paraffin-embedded tissue in IHC Specimen Transport Kit Alternative Specimen(s) Unstained charged (+) slides collected in IHC Specimen Transport Kit (x5) Minimum Volume IHC Specimen Transport Kit Collection Instructions Lung tissue biopsy formalin-fixed paraffin-embedded block or charged/+slides from formalin-fixed paraffin embedded tissue. Specimen must be fixed in 10% neutral buffered formalin. Fixation between 6 and 48 hours is recommended. Pathology report must accompany paraffin block or slides. Information required in this report include: Physician identification specimen identifiers (case and block number) specimen site and type tissue processing used (routine or microwave) type of fixative time and duration of fixation pathologic diagnosis. Do not freeze.
Container Temp
Room Temperature (1)
Container Volume
-
Test Info
FISH ALK 2p23 Rearrangement Lung Cancer (NSCLC) - Non-small cell lung cancer is the leading cause of cancer death worldwide. Tyrosine kinase inhibitors have been demonstrated to reduce lung cancer cell proliferation. The therapeutic efficacy of inhibiting ALK in tumors that were selected by ALK positivity using FISH has been demonstrated in an early-phase clinical trial of a small molecular inhibitor of the ALK tyrosine kinase. The Vysis ALK Break Apart FISH probe kit is a qualitative test to detect rearrangements involving the ALK gene in formalin-fixed paraffin embedded non-small cell lung cancer tissue specimens to aid in identifying those patients eligible for treatment with XALKOR (crizotinib).
Shipping Instructions
Transport Container IHC Specimen Transport Kit Transport Temperature Room temperature Specimen Stability Room temperature: Indefinite Refrigerated: Indefinite Frozen: Unacceptable