Result Test Name
QUEST EGFR MUTATION ANALYSIS
Laboratory
QUEST LAB
Result Test Code
123924767
Laboratory Test Name
QUEST LUNG CANCER MUTATION PANEL (EGFR KRAS ALK)
Reportable Test Name
-
Result LOINC
21665-5
Collection Container
PATH CONTAINER
Units
-
Collection Requirements
Preferred Specimen(s) Formalin-fixed paraffin-embedded tissue Alternative Specimen(s) 12 unstained charged (+) slides Minimum Volume 8 unstained charged (+) slides Collection Instructions Do not reject specimens. Send to laboratory for screening.
Container Temp
Room Temperature (1)
Container Volume
-
Test Info
Lung Cancer Mutation Panel (EGFR KRAS ALK) - This panel is comprised of mutational analysis of the EGFR and KRAS genes and assessment for ALK locus rearrangement using an FDA-cleared FISH assay. These are the most common tumor-associated genetic changes that have been shown to have prognostic and therapeutic consequences in non-small cell lung cancer (NSCLC) and help guide therapy. Patients with EGFR mutations are generally responsive to EGFR-directed kinase inhibitors whereas those with evidence of ALK gene rearrangements are candidates for treatment with the ALK inhibitor crizotinib. The presence of KRAS mutation in lung adenocarcinoma predicts for non-response to kinase inhibitors and for tumors with inferior outcome.
Shipping Instructions
Transport Container Formalin-fixed paraffin embedded tissue block Transport Temperature Room temperature Specimen Stability Room temperature: 5 years Refrigerated: 5 years Frozen: Unacceptable