Result Test Name
QUEST NRAS MUTATIONS ANALYSIS
Laboratory
QUEST LAB
Result Test Code
123002955
Laboratory Test Name
QUEST NRAS MUTATION ANALYSIS
Reportable Test Name
-
Result LOINC
21719-0
Collection Container
PATH CONTAINER
Units
-
Collection Requirements
Formalin-fixed paraffin-embedded tissue Alternative Specimen(s) 5 mL whole blood collected in an EDTA (lavender-top) tube or sodium heparin (green-top) tube 3 mL bone marrow aspirate submitted in an EDTA (lavender-top) tube or sodium heparin (green-top) tube 8 unstained charged (+) slides Minimum Volume 3 mL whole blood 1 mL bone marrow aspirate 4 unstained charged (+) slides Collection Instructions Paraffin block is the preferred sample type. Sample source and block ID are required on the requisition form and a pathology report must be submitted. Whole blood (acceptable): Follow standard whole blood collections procedures. Collect 3-5 mL whole blood in an EDTA tube. Record sample type collection time and date on both tube and requisition form. Bone marrow (acceptable) collection: The notation of sample type collection time and date on the tube and requisition form is required. Ship sample refrigerated or room temperature. Ship immediately to maintain stability. Do not reject specimens send to laboratory for screening.
Container Temp
Room Temperature (1)
Container Volume
-
Test Info
NRAS Mutation Analysis - NRAS mutations have been described in a variety of cancers including 3-5% of colorectal carcinomas 10-20% of melanomas and 10% of acute myeloid leukemias. Mutations leading to an amino acid substitution at positions 12 13 61 and 146 of NRAS are the most common in naturally occurring neoplasms. referred Specimen(s)
Shipping Instructions
Transport Container Formalin-fixed paraffin-embedded tissue block Transport Temperature Room temperature Specimen Stability Formalin-fixed paraffin-embedded tissue/slides Room temperature: 5 years Refrigerated: 5 years Frozen: Unacceptable Whole blood and bone marrow Room temperature: 72 hours Refrigerated: 72 hours Frozen: Unacceptable