Result Test Name
LIVER KIDNEY MICROSOMAL LKM-1 AB IGG
Laboratory
QUEST LAB
Result Test Code
123012636
Laboratory Test Name
QUEST AUTOIMMUNE HEPATITIS DIAGNOSTIC PANEL
Reportable Test Name
-
Result LOINC
47318-1
Collection Container
SST
Units
-
Collection Requirements
Preferred Specimen(s) 2.5 mL serum Minimum Volume 0.6 mL
Container Temp
Refrigerated (3)
Container Volume
2.500
Test Info
Autoimmune Hepatitis Diagnostic Panel - This panel may be helpful in the diagnostic evaluation of individuals with suspected autoimmune hepatitis (AIH). This panel includes an antinuclear antibody (ANA) immunofluorescence assay (IFA) screen performed on human epithelial type 2 (HEp-2) cells with reflex to titer and pattern; actin (smooth muscle) antibody (SMA); liver kidney microsome type 1 (LKM-1) antibody (IgG); and anti-mitochondrial antibody (AMA) with reflex to titer. The diagnosis of AIH is based on clinical features serologic profile and exclusion of resembling diseases such as viral hepatitis [1]. The detection of antibodies associated with AIH helps establish the diagnosis and differentiate AIH types. ANA and SMA are characteristic of type 1 AIH while LKM-1 antibody is characteristic of type 2 AIH [2]. ANAs are detected in 75% of patients with type 1 AIH but are also common in many other autoimmune diseases [1]. SMAs are present in approximately 85% of patients with type 1 AIH but can be detected in a range of other conditions such as viral hepatitis malignancies rheumatic diseases and nonalcoholic fatty liver disease [1]. LKM-1 antibody is specific for type 2 AIH and usually is not concurrent with ANA and SMA. Up to 20% of patients with AIH are negative for ANA SMA and LKM-1 antibody. In these patients testing antibodies associated with AIH such as AMA may help support the diagnosis [2]. AMA is the serologic hallmark of primary biliary cholangitis (PBC) but can also be detected in PBC-AIH overlap syndrome and type 1 AIH [1]. The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination finding
Shipping Instructions
Transport Container Transport tube Transport Temperature Refrigerated (cold packs) Specimen Stability Room temperature: 4 days Refrigerated: 7 days Frozen: 30 days Reject Criteria Hemolysis Lipemia